In The News
Enzyme-inhibitors treat drug-resistant epilepsy April 27, 2015
Tsuyoshi Inoue
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
A scheme of energy metabolic pathways in the brain. Glucose is transported into neurons and converted to pyruvate in glycolysis (pathway 1, brown). Ketone bodies directly activate the TCA cycle in neurons (pathway 2, green). Glucose is also transported into astrocytes (a type of glial cell) and converted to lactate by LDH, which is then released to neurons and converted to pyruvate by LDH (pathway 3, blue; the astrocyte-neuron lactate shuttle).
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